Welcome to the Dekker lab!

Welcome to the Dekker lab!

We study how a genome is organized in three dimensions inside the nucleus. The spatial organization of a genome plays important roles in regulation of genes and maintenance of genome stability. Many diseases, including cancer, are characterized by alterations in the spatial organization of the genome. How genomes are organized in three dimensions, and how this affects gene expression is poorly understood. To address this issue we study the genomes of human and yeast, using a set of powerful molecular and genomic tools that we developed.

We are currently seeking outstanding Bioinformaticians and Computational Biologists to join our multidisciplinary team to study the spatial organization of the human genome

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Welcome Allana!

Allana Schooley

Allana Schooley has joined the Dekker lab team as a postdoc! Allana recently graduated at the Friedrich Miescher Laboratory of the Max Planck Society in Tuebingen, Germany under the supervision of PD Dr. Wolfram Antonin. She produced her thesis on: “The histone demethylase LSD1 regulates nuclear envelope formation at the end of Mitosis” with the support of a Max Planck fellowship. We are very excited to have her in the lab!   … Read more!…

Marlies has Graduated at University of Groningen

Marlies (left) after graduation ceremony

Marlies has graduated! Back in Groningen, in the north of the Netherlands, Marlies Oomen has obtained her masters degree in Biology and celebrated after her graduation ceremony. Now a licensed biologist, Marlies will re-enter the Dekker lab as the newest grad student. We are excited for her return! We do however, feel a bit sorry for her, as she will once again come in to face the Worcester winter… … Read more!…

Condensin-driven remodelling of X chromosome topology during dosage compensation

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The three-dimensional organization of a genome plays a critical role in regulating gene expression, yet little is known about the machinery and mechanisms that determine higher-order chromosome structure. Here we perform genome-wide chromosome conformation capture analysis, fluorescent in situ hybridization (FISH), and RNA-seq to obtain comprehensive three-dimensional (3D) maps of the Caenorhabditis elegans genome and to dissect X chromosome dosage compensation, which balances gene expression between XX hermaphrodites and XO males. The dosage compensation complex (DCC), a condensin complex, binds to both hermaphrodite X chromosomes via sequence-specific recruitment elements on X (rex sites) to reduce chromosome-wide gene expression by half. … Read more!…